A phase I/II study of epertinib plus trastuzumab with or without chemotherapy in patients with HER2-positive metastatic breast cancer

Abstract Background Epertinib (S-222611) is a potent reversible inhibitor of HER2, EGFR and HER4.This trial evaluated the safety, tolerability, pharmacokinetics and antitumour activity of daily oral epertinib combined with trastuzumab (arm A), with trastuzumab plus vinorelbine (arm B) or with trastuzumab plus capecitabine (arm C), in patients with

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The Effects of Economic Sanctions on the Informal Economy

Countries often use economic sanctions to coerce other countries to change certain policies of which they do not Walker/Rollator Accessories approve.However, if sanctioned countries smuggle goods over the border, use informal financial intermediaries, and develop black markets to trade sanctioned goods, sanctions end up having a smaller impact, san

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